NIH “Two Strikes You’re Out” Rule, Two Years Later

By Bouvier Grant Group

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Once upon a time, one was allowed three submissions on an NIH grant application—your initial submission (A0), and two resubmissions after review (A1 and A2). In January 2009 NIH did away with the second resubmission, giving rise to what the scientific community not-so-fondly dubbed the “Two Strikes You’re Out” rule. This policy was instituted under the leadership of previous NIH Director Elias Zerhouni as part of the effort to Enhance Peer Review. The goal was to fund the best science in the shortest time period possible.

So two years out, how successful has this policy been? Today NIH released a letter it composed in response to one it received from members of the scientific community. Before the policy went into effect, funding for A0s had dropped dramatically, despite the fact that applications that initially scored in the top 20% were eventually funded (they went on to be funded as A1s and A2s after having to wait 1-2 years.) This trend appears to have reversed: The proportion of funded A1 applications has remained constant while the proportion of funded A0s has increased dramatically. The NIH letter goes on to supply data demonstrating that the policy has not had a negative effect on R01 funding for New and Early Stage Investigators. Read more, and if you haven’t already subscribed to NIH Deputy Director Sally Rockey’s blog “Rock Talk”, I highly recommend you do so.

Author:
Dr. Meg Bouvier

Margaret Bouvier received her PhD in 1995 in Biomedical Sciences from the Mount Sinai School of Medicine. After an NINDS post-doctoral fellowship, she worked as a staff writer for long-standing NIH Director Dr. Francis Collins in the Office of Press, Policy, and Communications for the Human Genome Project and NHGRI. Since 2007, Meg has specialized in editing and advising on NIH submissions, and began offering virtual courses in 2015. She's recently worked with more than 40% of the nation's highest-performing hospitals*, four of the top 10 cancer hospitals, three of the top five medical schools for research, and 14 NCI-designated cancer centers. Her experience at NIH as both a bench scientist and staff writer greatly informs her approach to NIH grantwriting. She has helped clients land over half a billion in federal funding. Bouvier Grant Group is a woman-owned small business.

*Our clients include 9 of the top 22 hospitals as recognized by the 2023/24 US News & World Report honor roll

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